| Relevance : |
In vitro study of ERBB2 proto-oncogene over-expression in human mammary epithelia; in vitro study of the effects of ERBB2 over-expression on epithelial morphology & adhesion |
| Description : |
Human mammary luminal epithelial cell line MTSV1-7 transfected with ERBB2 expression vector, enabling over-expression of ERBB2 proto-oncogene |
| Cell Line Type / Application : |
Transgenic cell line |
| Species / Origin : |
Human; derived from human mammary luminal epithelial cell line MTSV1-7 |
| Growth / Phenotype Keywords : |
Morphology; adhesion properties |
| Disease Keywords : |
Cancer; breast cancer |
| Recommended Growth Conditions : |
|
| References : |
D'Souza B & Taylor-Papadimitriou J, PNAS, 1994, v91 pp7202-7206 
D'Souza B et al, Oncogene, 1993, v8 pp1797-1806
Bartek J et al, PNAS, 1991, v88 pp3520-3524 |
| Notes : |
The MTSV1-7 ce1 cell line is an ideal tool for investigation of the role of the ERBB2 receptor proto-oncogene in breast cancer morphogenesis and adhesion. MTSV1-7 ce1 cells over-express the ERBB2 receptor, inducing a reduced ability to undergo morphogenesis in vitro, and reduced expression of surface adhesion molecules E-Cadherin and a2 integrin.
Inhibition of morphogenesis and transcription of adhesion molecules in human mammary epithelial cells can be affected by signals generated by the ERBB2 receptor, suggesting a role for ERBB2 over-expression in tumour progression and metastasis.
For other morphogenesis and mammary luminal epithelial cell lines, see also;
1-7 HB2 cell line |
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