| Relevance : |
Packaging cell line enabling production of high-titer, human complement-resistant recombinant retroviruses, with significantly reduced probability of replication-competent retrovirus generation |
| Description : |
HT1080-based packaging cell line enabling production of recombinant retroviral vectors with Moloney murine leukemia virus cores and cat endogenous virus RD114 virus envelopes |
| Cell Line Type / Application : |
Viral packaging / production line |
| Species / Origin : |
Human; for details of production of FLYRD18 cell line see Cosset F et al, Journal of Virology, 1995, v69 pp7430-7436 |
| Growth / Phenotype Keywords : |
Recombinant retroviral production |
| Disease Keywords : |
- |
| Recommended Growth Conditions : |
For recommended growth and recombinant retrovirus production conditions see Cosset F et al, Journal of Virology, 1995, v69 pp7430-7436 & Takeuchi Y et al, Journal of Virology, 1994, v68 pp8001-8007 |
| References : |
Cosset F et al, Journal of Virology, 1995, v69 pp7430-7436 
Takeuchi Y et al, Journal of Virology, 1994, v68 pp8001-8007 |
| Notes : |
The FLYRD18 recombinant retroviral packaging cell line enables production of high-titer recombinant retrovirus vectors with Moloney murine leukemia virus cores, and cat endogenous virus RD114 virus envelopes.
The vectors demonstrate high resistance to the inhibitory effects of human serum/complement, increasing penetration of the vector, and making the system ideal for in vivo gene transfer.
For more high-titer retroviral gene transfer packaging systems, see also;
FLYA13 cell line; WE & pBabe gene transfer system |
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