| Relevance : |
Controlled in vitro study system for T cell receptor function and activation; in vitro study of action/efficacy of TCR protagonists/antagonists |
| Description : |
T lymphoid cell line expressing functional CD3 and TCR specific for influenza virus haemagglutinin peptide HA307-319 in context of human HLA-DR1 MHC II molecule |
| Cell Line Type / Application : |
Transgenic cell line |
| Species / Origin : |
Human; Jurkat JRT3T3.5 transfected with an expression vector encoding HA1.7 TCR a and b chain sequences (encoding a TCR specific to influenza virus haemagglutinin peptide HA307-319). Transfected cells were sorted for high CD3 expression, CH7C17 clone isolated as a high CD3, high specificity clone. |
| Growth / Phenotype Keywords : |
Functional TCR/CD3 expression |
| Disease Keywords : |
Immune response / disease |
| Recommended Growth Conditions : |
CH7C17 can be grown in RPMI 1640 with 10% FCS, supplemented with hygromycin (400mg/ml), puromycin (4mg/ml) |
| References : |
Hewitt CRA et al, Journal of Experimental Medicine, 1992, v175 pp1493-1499  |
| Notes : |
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