| Antigen: |
XPG |
| Relevance: |
XPG is a DNA endonuclease
that is essential for the dual incision step of nucleotide
excision repair
(cleaves 3' of the DNA lesion). XPG can be involved
in the DNA replication and repair deficiency syndromes
Cockayne Syndrome and Xeroderma pigmentosa. |
| Clone: |
8H7/XPG |
| Subclass: |
IgG2a |
| Applications: |
Western blot, Immunoprecipitation, Immunohistochemistry |
| Immunogen: |
recombinant XPG protein produced in baculovirus |
| Reactivity: |
Human |
| Species raised in: |
Mouse: Balb/c |
| Fusion partner: |
Sp2 |
| Recommended growth conditions: |
DMEM 5% FCS |
| References: |
Evans E et al. 1997. EMBO J. 16:625-638. 
Araujo SJ et al. 2001. Mol. Cell. Biol. 21(7):2281-91. |
| Notes: |
Works well on crude cell extract. Stains XPG in the nuclei of human cells. Positive control: LnCap cells. 185 kDa MW. |
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