| Antigen: |
Sialoadhesin domains 1-4
(Siglec0-1) |
| Relevance: |
The siglecs are a family
of membrane bound lectins (of the immunoglobulin superfamily)
that bind sialic acid and mediate cell-cell interactions.
Family members include sialoadhesin, CD22 and CD33.
Sialoadhesin is a macrophage-specific cell adhesion
molecule that is expressed on activated macrophages
in chronic inflammation and in tumours. |
| Clone: |
HSn 7D2 |
| Subclass: |
IgG1 |
| Applications: |
Immunohistochemistry (paraffin
embedded, acetone fixed, fozen), FACS, RIA, ELISA |
| Immunogen: |
Fc fusion protein containing N-terminal 4 domains of human sialoadhesin. |
| Reactivity: |
Human |
| Species raised in: |
Mouse: Balb/c |
| Fusion partner: |
Sp2/0 Ag.14 |
| Recommended growth conditions: |
DMEM + 5%FCSDMEM 5% FCS |
| References: |
Hartnell A et al. 2001. Blood. 97(1):288-96. 
Steiniger B et al. 1997. Immunology. 92:307-316 |
| Notes: |
- |
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