| Antigen: |
Phosphorylated RNA polymerase II (RNA pol II). Epitope: C-terminal repeat of the largest subunit of RNAPII |
| Relevance: |
RNAPII is an essential component of the RNAP II transcription elongation complex. Recruitment of RNA processing factors to the elongation complex is coordinated by the phosphorylation of Serine-2 and Serine-5 residues within the C-terminal repeat (YSPTSPS) domain of the largest subunit of RNAPII. |
| Clone: |
CTD 8A7 |
| Subclass: |
IgM |
| Applications: |
ELISA, Western blot |
| Immunogen: |
Peptide: 10 repeats of synthetic peptide YSPTSPS using chemically sythesized phospho-ser 5. |
| Reactivity: |
Human and S. cerevisiae |
| Species raised in: |
Mouse: Balb/c |
| Fusion partner: |
Sp2/0 Ag.14 |
| Recommended growth conditions: |
DMEM 5% FCS |
| References: |
Otero G et al. 1999. Mol. Cell. 3:109-118  |
| Notes: |
- |
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