| Antigen: |
Retinoblastoma (Rb1) |
| Relevance: |
The Retinoblastoma protein (Rb) is a transcription factor that controls cell cycle progression (at the G1/S phase transition) through its repression of E2F-mediated transcription. Mutation of the Rb gene is found frequently in human sarcomas, lung, bladder and breast carcinomas and is the molecular basis for hereditary disposition to retinoblastoma. |
| Clone: |
Rb1 |
| Subclass: |
IgG1 |
| Applications: |
Immunoprecipitation, Immunohistochemistry
(Frozen) |
| Immunogen: |
Rb-b-galactosidase fusion protein spanning nucleotides 1126-1973 and representing 283 amino acids of Rb cDNA |
| Reactivity: |
Human |
| Species raised in: |
Mouse: Balb/c |
| Fusion partner: |
Sp2/0-Ag14 |
| Recommended growth conditions: |
DMEM + 10% FCS |
| References: |
Grand R et al. 1989. Oncogene.
4:1291-1298 
Bartek J et al. 1992. Oncogene. 7:101-108
Bartkova J et al. 2003. J. Pathol. 200(2):149-56 |
| Notes: |
Use: In sensitive assays
for Rb complexed to the T antigen |
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