p73, a member of the p53-related nuclear transcription factors, functions in a manner analogous to p53 by inducing tumor cell apoptosis and participating in the cell cycle checkpoint control through transactivating an overlapping set of p53/p73-target genes. p73 is expressed as a number of isoforms including alpha, beta and gamma. Delta p73 has oncogenic potential. Several lines of evidence suggest that p73 can induce tumor cell apoptosis in a p53-dependent and p53-independent manner. Where tumour resistance is to p53-dependent apoptotic program is seem, the p73 mediated p53-idependant pathway to apoptosis may be particularly useful.
Applications:
Western blot, Immunoprecipitation and Immunofluorescence
Immunogen:
aa 1-131 of p73
Reactivity:
Human
Species raised in:
Rabbit
References:
-
Notes:
Recognises alpha and beta isoforms but not delta
Suggested dilution for western: 1/1000
Recognises endogenous faintly but is not clean; best for when p73 is being over expressed.
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