| Antigen: |
Protein kinase Cα. Epitope: within the variable region V3 PKCα (the site of limited proteolysis on the native enzyme). |
| Relevance: |
Protein Kinase C is a family of serine/threonine protein kinases that are activated by Ca2+, diacylglycerol and membrane phospholipids (phosphatidylserine). MC5 blocks partial proteolysis of PKC by trypsin in vitro. Fab fragment inhibits phorbol-ester-induced down-regulation of PKC in a rodent gloma cell line. |
| Clone: |
MC5 |
| Subclass: |
IgG2a |
| Applications: |
Immunoprecipitation, ELISA, Radioimmunoassay, Western blot |
| Immunogen: |
Purified bovine brain protein kinase C |
| Reactivity: |
- |
| Species raised in: |
Mouse: Balb/c |
| Fusion partner: |
P3x63 |
| Recommended growth conditions: |
DMEM 5% FCS |
| References: |
Young S et al. 1988. Eur. J. Biochem.173:247-252. 
Ng T et al. 1999. EMBO J. 18:3909-3923. |
| Notes: |
- |
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