| Antigen: |
Placental alkaline phosphatase (PLAP) |
| Relevance: |
Alkaline phosphatases are phosphodiesterases. The placental-specific isozyme of Alkaline Phosphatase (PLAP) is found in trophoblast cells of normal human mature placenta, seminomas of testis and ovarian carcinomas. Detection of alkaline phosphatase in serum is a marker for ovarian and testicular cancer. H17E2 can be used for diagnosing, staging and monitoring of placental alkaline phosphatase-positive neoplasms of testicular, ovarian and cervical origin. H17E2 cross-reacts with the related testis form of alkaline phosphatase. |
| Clone: |
H17E2 |
| Subclass: |
IgG1 |
| Applications: |
ELISA, Immunohistochemistry (Frozen) |
| Immunogen: |
Placental membranes prepared
from fresh term placenta |
| Reactivity: |
Human |
| Species raised in: |
Mouse: Balb/c |
| Fusion partner: |
NS1/1-Ag-4-1 |
| Recommended growth conditions: |
DMEM 5% FCS |
| References: |
Travers P & Bodmer
W. 1984. Int. J. Cancer. 33:633-641 
Epenetos AA et al. 1984. Br. J. Cancer. 49:11-15
Tucker D et al. 1985. Brit. J. Cancer. 51:631-639
Epenetos A et al. 1985. Brit. J. Cancer. 51:641-644 |
| Notes: |
67 kDa MW |
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