| Antigen: |
Migration inhibitory factor related proteins (MRP) of 8 kDa (MRP-8) and 14 kDa (MRP-14). |
| Relevance: |
MRP-8 and MRP-14 are cytosolic calcium-binding proteins of 8kDa and 14kDa that form a heterodimer. MRP-8 and MRP-14 are expressed in peripheral blood monocytes, neutrophils and keratinocytes (mature). Expression is lost on tissue maturation of monocytes to macrophages. MRP-14 may be associated with monocyte and neutrophil activation and the accumulation of these cells in inflammatory sites. |
| Clone: |
5.5 |
| Subclass: |
IgG1 |
| Applications: |
Immunohistochemistry (frozen sections), Immunoprecipitation, Western blot |
| Immunogen: |
Acute monocytic leukaemia cells. |
| Reactivity: |
Human |
| Species raised in: |
Mouse |
| Fusion partner: |
|
| Recommended growth conditions: |
DMEM 5% FCS |
| References: |
Hogg
N et al. 1989. Eur. J. Immunol. 19:1053-1061. 
Hessian
PA et al. 2001. Eur. J. Biochem. 268:353-363
|
| Notes: |
Positive control: neutrophil lysate (particularly neutrophils from spleen) |
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