| Antigen: |
Keratin 8 |
| Relevance: |
Keratins are a family of intermediate filament proteins that assemble into filaments through forming heterodimers of one type I keratin (keratins 9 to 23) and one type II keratin (keratins 1 to 8). Keratins demonstrate tissue- and differentiation-specific expression profiles. Keratins 8 and 18 are two of the first keratins expressed in the embryo, and persist into adult tissues as the keratin pair representing minimal epithelial keratin expression. Keratins 8 and 18 are major components of all simple epithelia (but not of stratified squamous epithelia) and adenocarcinomas. Keratin 8 is the tissue polypeptide antigen (TPA) reported to be present in the serum of cancer patients. |
| Clone: |
LP3K |
| Subclass: |
IgG1 |
| Applications: |
Western blot, Immunohistochemistry |
| Immunogen: |
Sonicated cytoskeleton fractions ( insoluble in 1% Nonidet-P40) from SV40 transformed neonatal keratinocytes. |
| Reactivity: |
Human |
| Species raised in: |
Mouse: Balb/c |
| Fusion partner: |
Sp2/0-Ag14 |
| Recommended growth conditions: |
DMEM 5% FCS |
| References: |
Lane EB et al. 1985. Ann. NY Acad. Sci. 455:241-258  |
| Notes: |
52 kDa MW |
For further information about antibodies from CRT or to discuss sales or licensing options, please contact us at reagents@cancertechnology.com
Please note that CRT supplies to distributors only. However, we are happy to direct researchers to the appropriate commercial party to obtain antibodies within our portfolio. Click here to view disclaimer information. |
