| Antigen: |
Keratin 7,13,17&18 |
| Relevance: |
Keratins are a family of intermediate filament proteins that assemble into filaments through forming heterodimers of one type I keratin (keratins 9 to 23) and one type II keratin (keratins 1 to 8). Keratins demonstrate tissue- and differentiation-specific expression profiles. Keratins 7 and 8 are two closely related type II keratins characteristic of simple epithelia. Keratin 7 is less widespread than keratin 8 and is expressed in sebaceous and sweat glands and some cells of the inner hair root sheath. Keratin 7 is often co-expressed with keratin 19. Keratin 17 is expressed in suprabasal keratinocytes of wounded epidermis. Keratins 8 and 18 are two of the first keratins expressed in the embryo, and persist into adult tissues as the keratin pair representing minimal epithelial keratin expression. Keratins 8 and 18 are major components of all simple epithelia (but not of stratified squamous epithelia) and adenocarcinomas. LdS 23 is useful for studies of epithelial cells and tumour origin. |
| Clone: |
LdS 23 |
| Subclass: |
IgG1 |
| Applications: |
Immunohistochemistry (frozen
sections), Immunofluorescence (frozen sections) |
| Immunogen: |
Cytoskeletons of the human urothelial RT4 cell line |
| Reactivity: |
Human |
| Species raised in: |
Mouse |
| Fusion partner: |
- |
| Recommended growth conditions: |
DMEM 5% FCS |
| References: |
-
|
| Notes: |
- |
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