| Antigen: |
Keratin 7 (some weak reactivity with keratin 8 and other type II keratins). |
| Relevance: |
Keratins are a family of intermediate filament proteins that assemble into filaments through forming heterodimers of one type I keratin (keratins 9 to 23) and one type II keratin (keratins 1 to 8). Keratins demonstrate tissue- and differentiation-specific expression profiles. Keratins 7 and 8 are two closely related type II keratins characteristic of simple epithelia. Keratin 7 is less widespread than keratin 8 and is expressed in sebaceous and sweat glands and some cells of the inner hair root sheath. Keratin 7 is often co-expressed with keratin 19. |
| Clone: |
LP1K |
| Subclass: |
IgG1 |
| Applications: |
Immunohistochemistry, Western blot |
| Immunogen: |
Sonicated cytoskeleton
fractions ( insoluble in 1% Nonidet-P40) from SV40 transformed
neonatal keratinocytes |
| Reactivity: |
Mammalian, Amphibian |
| Species raised in: |
Mouse: Balb/c |
| Fusion partner: |
Sp2/0-Ag14 |
| Recommended growth conditions: |
DMEM 5% FCS |
| References: |
Lane
EB et al. 1985. Ann. NY Acad. Sci. 455:241-258 
Markey AC et al. 1992. Br. J. Dermatol. 126:154-160
|
| Notes: |
Immunohistology Poor reactivity
with fixed tissue, 54 kDa MW. Some weak reactivity
with keratin 8 and other type II keratins. |
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