| Antigen: |
Keratin 10 |
| Relevance: |
Keratins are a family
of intermediate filament proteins that assemble into
filaments through forming heterodimers of one type I
keratin (keratins 9 to 23) and one type II keratin (keratins
1 to 8). Keratins demonstrate tissue- and differentiation-specific
expression profiles. Keratin 10 is differentiation-specific
keratin that is one of the predominant keratins in suprabasal
keratinocytes in stratified epthelia. Keratin
10 is a suprabasal marker of differentiation in stratified
squamous epithelia. Mutations in keratin 10 cause
epidermolytic hyperkeratosis. LH2 does not react
with any tumour tissue regardless of histological classification. |
| Clone: |
LH2 |
| Subclass: |
IgG1 |
| Applications: |
Immunohistochemistry (Frozen
sections) |
| Immunogen: |
Extract of skin from psoriasis patient |
| Reactivity: |
Human |
| Species raised in: |
Mouse |
| Fusion partner: |
Sp2 |
| Recommended growth conditions: |
DMEM 5% FCS |
| References: |
Broekaert
D et al. 1990. Arch. Dermatol. Res. 282:383-391 
Porter RM et al. 2000. Lab Invest. 80(11):1701-10
|
| Notes: |
LH2 is monospecific and has high affinity. |
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