| Antigen: |
Integrin alpha 2b (CD41) |
| Relevance: |
Integrins are heterodimeric
cell surface receptors composed of a and b subunits,
which mediate cell-cell and cell-extracellular matrix
attachments. Aberrant integrin expression has been found
in many epithelial tumours. Changes in integrin expression
have been shown to be important for the growth and early
metastatic capacity of melanoma cells. Integrin
alpha 2b
(CD41) and integrin ß3
(CD61) associate to form the heterodimer integrin a2bß3
(CD41/CD61; GPIIb/IIIa), a fibronectin receptor expressed
in platelets. M148 prevents aggregation of platelets.
Used for imaging and therapy of thrombi. M148 binds
to some medulloblastoma and neuroblastoma cells and
rhabdomyosarcoma and certain other solid tumours. No
binding is observed to marrow constituents other than
platelets and megakaryocytes. |
| Clone: |
M148 |
| Subclass: |
IgG1 |
| Applications: |
Immunoprecipitation |
| Immunogen: |
Homogenized human medulloblastoma
tissue |
| Reactivity: |
Human |
| Species raised in: |
Mouse: Balb/c. |
| Fusion partner: |
P3-X63-Ag8-653 |
| Recommended growth conditions: |
DMEM + 5% FCS |
| References: |
Jones D et al. 1984. Brit.
J. Haem. 57:621-631  |
| Notes: |
|
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