| Antigen: |
Integrin a2bß3 (CD41 &
CD61) |
| Relevance: |
Integrins are heterodimeric
cell surface receptors composed of a and ß subunits,
which mediate cell-cell and cell-extracellular matrix
attachments. Aberrant integrin expression has been found
in many epithelial tumours. Changes in integrin expression
have been shown to be important for the growth and early
metastatic capacity of melanoma cells. Integrin
a2b (CD41)
and integrin ß3 (CD61) associate
to form the heterodimer integrin a2bb3
(CD41/CD61; GPIIb/IIIa), a fibronectin receptor expressed
in platelets. P256 has potential use for imaging
of thrombi. P256 induces aggregation of normal platelets
in plasma. |
| Clone: |
P256 |
| Subclass: |
IgG1 |
| Applications: |
Immunofluorescence, Immunoprecipitation, Western blot |
| Immunogen: |
Peripheral blood mononuclear cells |
| Reactivity: |
- |
| Species raised in: |
Mouse: Balb/c. |
| Fusion partner: |
P3-NS1/1-Ag4-1 |
| Recommended growth conditions: |
DMEM + 5% FCS |
| References: |
Bai Y et al. 1983. Eur.
J. Immunol. 13:521-527 
Bachelot C et al. 1990. Eur. J. Biochem. 190:177-183 |
| Notes: |
135 kDa component of the glycoprotein IIa/IIIb complex on platelet and megakaryocytes cell membranes. |
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