| Antigen: |
Integrin αL, αM,
αX/β2 (CD11/ CD18) |
| Relevance: |
Integrins are heterodimeric
cell surface receptors composed of a and ß subunits,
which mediate cell-cell and cell-extracellular matrix
attachments. Aberrant integrin expression has
been found in many epithelial tumours. Changes
in integrin expression have been shown to be important
for the growth and early metastatic capacity of melanoma
cells. CD18 associates with CD11a (integrin αL)
to form leukocyte function-associated antigen-1 (LFA-1),
CD11b (integrin αM) to
form Mac-1 and CD11c (integrin αX)
to form gp150/95. CD11/CD18 integrins bind various
ICAMs. 24 may be used as a reporter of the activation
state of CD11/CD18 receptors, which are activated following
exposure to Mg2+ or Mn2+. |
| Clone: |
24 |
| Subclass: |
IgG1 |
| Applications: |
Radioimmunoassay, FACS, Immunoprecipitation |
| Immunogen: |
Fibronectin-purified human
monocytes |
| Reactivity: |
Human |
| Species raised in: |
Mouse: Balb/c |
| Fusion partner: |
Sp2/O-Ag14 |
| Recommended growth conditions: |
E4 + 10% FCS |
| References: |
Hogg
N and Selvendran Y. 1985. Cell. Immunol. 92:247-253 
McDowall
A et al. 2003. J. Clin. Invest. 111(1):51-60 |
| Notes: |
Positive control: tonsil.
CD18: 95 kDa, CD11: 180kDa |
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