| Antigen: |
Interleukin-12 (IL12) p40 subunit |
| Relevance: |
IL-12 is a heterodimeric
cytokine comprised of p35 and p40 subunits. IL-12 plays
a central role in mediating cell-mediated immunity,
promoting differentiation of CD4+ T cells to the Th1
subset and of CD8+ T cells into mature cytotoxic T lymphocytes
(CTLs). IL-12 is a potent stimulator of NK cells. IL-12
therapy has been suggested as a method of enhancing
cytocidal anti-tumour immune responses. 1-1D5 is a neutralising
antibody that blocks IL-12 induced proliferation of
PBL. Potential use in suppressing chronic inflammatory
diseases and graft rejection. Reacts with immobilised
IL-12. Captures human p40 murine p35 chimeric protein. |
| Clone: |
1-1D5 |
| Subclass: |
IgG1 |
| Applications: |
Radioimmunoassay, ELISA, Western blot, Neutralising |
| Immunogen: |
Recombinant IL-12 human
produced by baculovirus |
| Reactivity: |
Human |
| Species raised in: |
- |
| Fusion partner: |
Sp2 |
| Recommended growth conditions: |
DMEM + 5% FCS |
| References: |
Carter RW et al. 1997.
Hybridoma 16(4):363-369  |
| Notes: |
Tested against baculovirus
and CCHO derived recombinant IL-12 |
For further information about antibodies from CRT or to discuss sales or licensing options, please contact us at reagents@cancertechnology.com
Please note that CRT supplies to distributors only. However, we are happy to direct researchers to the appropriate commercial party to obtain antibodies within our portfolio. Click here to view disclaimer information. |
