| Antigen: |
Interleukin-12 (IL12) p40 subunit |
| Relevance: |
IL-12 is a heterodimeric cytokine comprised of p35 and p40 subunits. IL-12 plays a central role in mediating cell-mediated immunity, promoting differentiation of CD4+ T cells to the Th1 subset and of CD8+ T cells into mature cytotoxic T lymphocytes (CTLs). IL-12 is a potent stimulator of NK cells. IL-12 therapy has been suggested as a method of enhancing cytocidal anti-tumour immune responses. |
| Clone: |
1-1A4 |
| Subclass: |
IgG1 |
| Applications: |
ELISA, Radioimmunoassay |
| Immunogen: |
Recombinant IL-12 human
produced in Baculovirus |
| Reactivity: |
Human |
| Species raised in: |
- |
| Fusion partner: |
Sp2 |
| Recommended growth conditions: |
DMEM + 5% FCS |
| References: |
Carter RW et al. 1997.
Hybridoma. 16(4):363-369  |
| Notes: |
Tested against baculovirus
and CCHO derived recombinant IL-12 |
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