| Antigen: |
Integrin ß3 chain (CD61) |
| Relevance: |
Integrins are heterodimeric
cell surface receptors composed of a and β subunits,
which mediate cell-cell and cell-extracellular matrix
attachments. Aberrant integrin expression has been found
in many epithelial tumours. Changes in integrin expression
have been shown to be important for the growth and early
metastatic capacity of melanoma cells. Integrin
ß3 is expressed in osteoclasts,
megacaryocytes and platelets. MHF4 may be used to identify
osteoclasts in tissue sections and bone cell suspensions.
The MHF4 epitope is different to the F11 epitope. |
| Clone: |
MHF4 |
| Subclass: |
IgG1 |
| Applications: |
Immunohistochemistry(Frozen, Acetone Fixed), Immunoprecipitation, FACS |
| Immunogen: |
A bone cell suspension containing osteoclasts, osteoblasts and bone marrow cells obtained from the long bones of newborn Sprague Dawley rats. |
| Reactivity: |
Rat, Human |
| Species raised in: |
Mouse: Balb/c |
| Fusion partner: |
- |
| Recommended growth conditions: |
DMEM 5% FCS |
| References: |
Helfrich MH et al. 1992. J. Bone Miner. Res. 7(3):345-351.  |
| Notes: |
A heterodimeric molecule with a characteristic shift in apparent molecular mass on reduction (137/78 kDa nonreduced; 118/100 kDa reduced). |
For further information about antibodies from CRT or to discuss sales or licensing options, please contact us at reagents@cancertechnology.com
Please note that CRT supplies to distributors only. However, we are happy to direct researchers to the appropriate commercial party to obtain antibodies within our portfolio. Click here to view disclaimer information. |
