| Antigen: |
Integrin β3 (CD61) |
| Relevance: |
Integrins are heterodimeric
cell surface receptors composed of a and β subunits,
which mediate cell-cell and cell-extracellular matrix
attachments. Aberrant integrin expression has been found
in many epithelial tumours. Changes in integrin expression
have been shown to be important for the growth and early
metastatic capacity of melanoma cells. Integrin ß3
is expressed in osteoclasts, megacaryocytes and platelets.
The F11 epitope is different to the MHF4 epitope. |
| Clone: |
F11 |
| Subclass: |
IgG1 |
| Applications: |
Immunoprecipitation, Immunohistochemistry (frozen, and formulin fixed), FACS, Neutralising |
| Immunogen: |
A bone cell suspension containing osteoclasts, osteoblasts and bone marrow cells obtained from the long bones of newborn Sprague Dawley rats. |
| Reactivity: |
Rat, weakly reactive with
human |
| Species raised in: |
Mouse: Balb/c |
| Fusion partner: |
X63-Ag8 |
| Recommended growth conditions: |
DMEM 5% FCS |
| References: |
Helfrich
MH et al. 1992. J. Bone Miner. Res. 7(3):335-343 
Helfrich MH et al. 1992. J. Bone Miner. Res. 7(3):345-351.
Thompson RD et al. 2000. J. Immunol. 165(1):426-34
Shankar
G et al. 1993. J Cell Sci. 105; 61-68. |
| Notes: |
The antibody may be used to identify ostoclasts in tissue sections and bone cell suspensions. |
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