| Antigen: |
Integrin αV (CD51) |
| Relevance: |
Integrins are heterodimeric
cell surface receptors composed of α and ß subunits,
which mediate cell-cell and cell-extracellular matrix
attachments. Aberrant integrin expression has been found
in many epithelial tumours. Changes in integrin expression
have been shown to be important for the growth and early
metastatic capacity of melanoma cells. Integrin αV
associates with integrin ß3
to form the osteoclast functional antigen (vitronectin
receptor). Integrin αV
is found in osteoclasts, placenta, melanoma cell lines
and some epithelial cell lines. Expression of integrin
αV
increases with melanoma progression. 23C6 may
be useful for bone resorption modulation, osteoclast
identification, receptor purification, malignant melanoma
identification and treatment. |
| Clone: |
13C2 |
| Subclass: |
IgG1 |
| Applications: |
Immunohistochemistry (Acetone Fixed, Frozen), FACS, Immunoprecipitation |
| Immunogen: |
A cell suspension containing
osteoclasts from osteoclastomas |
| Reactivity: |
Human |
| Species raised in: |
Mouse: Female Balb/c |
| Fusion partner: |
P3X63/Ag8 |
| Recommended growth conditions: |
DMEM + 5% FCS |
| References: |
Horton
MA et al. 1985. Cancer Res. 45:5663-5669 
Levy L et
al. 2000. Mol. Biol. Cell. 11(2):453-66 (flow cytometry)
|
| Notes: |
- |
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