| Antigen: |
Integrin αM (CD11b;
Mac-1α subunit) |
| Relevance: |
Integrins are heterodimeric cell surface receptors composed of α and β subunits, which mediate cell-cell and cell-extracellular matrix attachments. Aberrant integrin expression has been found in many epithelial tumours. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells. Integrin αM is found in neutrophils, monocytes and NK cells. Patients lacking integrin aM molecules have immune deficiency symptoms and commonly subject to bacterial and fungal infections. ICRF 44 blocks some functions of Mac-1. |
| Clone: |
ICRF 44 |
| Subclass: |
IgG1 |
| Applications: |
Immunohistochemistry (Frozen), Immunoprecipitation, FACS |
| Immunogen: |
Rheumatoid synovial cells and human monocytes. |
| Reactivity: |
Human, primate |
| Species raised in: |
Mouse: Balb/c. |
| Fusion partner: |
Sp 2/0 |
| Recommended growth conditions: |
DMEM + 5% FCS |
| References: |
Malhotra.V
et al. 1986. Eur. J. Immunology. 16:1117-1123. 
Leucocyte
Typing III. Edited by McMichael AJ et al. 1987
|
| Notes: |
Recognises the 160 kDa alpha subunit CD11b (of CD11b/CD18; alphaM beta2). Positive control: monocytes or neutrophils |
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