| Antigen: |
Integrin α6 (CD49f) |
| Relevance: |
Integrins are heterodimeric
cell surface receptors composed of α and β
subunits, which mediate cell-cell and cell-extracellular
matrix attachments. Aberrant integrin expression has
been found in many epithelial tumours. Changes in integrin
expression have been shown to be important for the growth
and early metastatic capacity of melanoma cells. Integrin
α6 is found on epithelial and
endothelial basement membranes and colorectal carcinoma.
Integrin a6
associates with integrin β4
to form integrin α6β4,
which is one of the most abundant keratinocyte integrins
and binds laminin. MP 4F10 can be used in clinical studies
for tumour grading - stains moderately and well-differentiated
colorectal adenocarcinoma |
| Clone: |
MP 4F10 |
| Subclass: |
IgG2b |
| Applications: |
Immunoprecipitation, Immunohistochemistry (frozen sections), FACS |
| Immunogen: |
SW1222 human colorectal
cell line |
| Reactivity: |
Human |
| Species raised in: |
Mouse: Balb/c |
| Fusion partner: |
P3/NS1/1-Ag4-1 |
| Recommended growth conditions: |
DMEM + 5% FCS |
| References: |
Anbazhagan
R et al. 1995. J. Pathol. 176:227-232 
Levy L et
al. 2000. Mol. Biol. Cell. 11(2):453-66
|
| Notes: |
No reaction on fixed formalin tissue |
For further information about antibodies from CRT or to discuss sales or licensing options, please contact us at reagents@cancertechnology.com
Please note that CRT supplies to distributors only. However, we are happy to direct researchers to the appropriate commercial party to obtain antibodies within our portfolio. Click here to view disclaimer information. |
