| Antigen: |
Integrin a2 (CD49b) |
| Relevance: |
Integrins are heterodimeric
cell surface receptors composed of α and β
subunits, which mediate cell-cell and cell-extracellular
matrix attachments. Aberrant integrin expression has
been found in many epithelial tumours. Changes in integrin
expression have been shown to be important for the growth
and early metastatic capacity of melanoma cells. Integrin
α2
associates with integrin ß1
(CD29) to form the heterodimer integrin a2ß1,
which is one of the most abundant keratinocyte integrins,
is found distributed in the basal layer of epidermis
and binds collagen. HAS-3 co-precipitates integrin a2ß1
from keratinocytes and inhibits HGF-induced branching
morphogenesis and motility of human mammary epithelial
HB2 cells in collagen. |
| Clone: |
HAS-3 |
| Subclass: |
IgG2a |
| Applications: |
Immunoprecipitation, FACS, Immunohistochemistry (frozen and formulin) |
| Immunogen: |
Whole human keratinocytes |
| Reactivity: |
Human |
| Species raised in: |
Mouse |
| Fusion partner: |
Sp2 |
| Recommended growth conditions: |
DMEM + 10% FCS |
| References: |
Tenchini
ML et al. 1993. Cell. Adhes. and Comm. 1:55-66 
Alford D et al. 1998. J. Cell Sci. 111:521-32
|
| Notes: |
- |
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