| Antigen: |
Integrin α2 (CD49b) |
| Relevance: |
Integrins are heterodimeric cell surface receptors composed of α and β subunits, which mediate cell-cell and cell-extracellular matrix attachments. Aberrant integrin expression has been found in many epithelial tumours. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells. Integrin a2 associates with integrin b1 (CD29) to form the heterodimer integrin a2b1, which is one of the most abundant keratinocyte integrins, is found distributed in the basal layer of epidermis and binds collagen. HAS-4 co-precipitates integrin a2b1 from keratinocytes and inhibits HGF-induced branching morphogenesis and motility of human mammary epithelial HB2 cells in collagen. |
| Clone: |
HAS-4 |
| Subclass: |
IgG2a |
| Applications: |
Immunoprecipitation, Immunohistochemistry(formaldehyde), FACS |
| Immunogen: |
- |
| Reactivity: |
Human |
| Species raised in: |
Mouse |
| Fusion partner: |
Sp2 |
| Recommended growth conditions: |
DMEM + 5% FCS |
| References: |
Tenchini
ML et al. 1993. Cell. Adhes. and Comm. 1:55-66 
Alford D
et al. 1998. J. Cell Sci. 111:521-32.
|
| Notes: |
|
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