| Antigen: |
Integrin αV (CD51) |
| Relevance: |
Integrins are heterodimeric
cell surface receptors composed of α and ß subunits,
which mediate cell-cell and cell-extracellular matrix
attachments. Aberrant integrin expression has been found
in many epithelial tumours. Changes in integrin expression
have been shown to be important for the growth and early
metastatic capacity of melanoma cells. Integrin αV
associates with integrin ß3
to form the osteoclast functional antigen (vitronectin
receptor). Integrin aV
is found in osteoclasts, placenta, melanoma cell lines
and some epithelial cell lines. Expression of integrin
αV
increases with melanoma progression. |
| Clone: |
P2W7 |
| Subclass: |
IgG1 |
| Applications: |
Immunoprecipitation, FACS,
Immunofluorescence, Western blot |
| Immunogen: |
Ocular melanoma cell line (V+B2) a clone expressing high levels of alpha-v,beta-1 |
| Reactivity: |
Human |
| Species raised in: |
- |
| Fusion partner: |
- |
| Recommended growth conditions: |
DMEM 5% FCS |
| References: |
Von Schlippe
M et al. 2000. J. Cell Sci. 113:425-37 
|
| Notes: |
Positive control lysate: A375M melanoma cell line. Human alpha v is about 150-160kDa under non-reducing conditions. Under reducing conditions it is cleaved into 2 bands of about 125-130kDa +20-25kDa. |
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