| Antigen: |
ICAM-1 (CD54) |
| Relevance: |
ICAMs are members of the
immunoglobulin superfamily that is characterised by
the presence of immunoglobulin-like domains. ICAM-1
is expressed in haemopoietic cells and vascular endothelium.
Cytokine activation causes ICAM-1 expression in other
cell types such as fibroblasts and keratinocytes.
ICAM-1 is involved in leukocyte recruitment and inflammation.
ICAM-1 binds LFA-1 (CD11a/CD18) and Mac-1
(CD11b/CD18). 15.2 blocks CD54 function. |
| Clone: |
15.2 |
| Subclass: |
IgG1 |
| Applications: |
Immunohistochemistry, Immunoprecipitation, FACS |
| Immunogen: |
Rheumatoid synovial cells
and human monocytes |
| Reactivity: |
Human |
| Species raised in: |
Mouse: Balb/c |
| Fusion partner: |
Sp 2/0 |
| Recommended growth conditions: |
E4 +10% FCS |
| References: |
Dransfield
I et al. 1992. J. Cell. Biol. 116:1527-1535 
Stanley
P et al. 2000. Biochem J. 351:79-86
|
| Notes: |
85-115 kDa MW. Positive control: tonsil |
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