| Antigen: |
HPV-16 E6 and HPV-18 E6 (early protein E6 on both HPV-16 and 18) |
| Relevance: |
The human papilloma virus (HPV) family of DNA tumor viruses includes HPV-16 and HPV-18, which are associated with a large proportion of cervical cancer cases. HPV early proteins E6 and E7 are the major viral oncoproteins that regulate cell proliferation through the inactivation of p53 and Rb1 tumour suppressor proteins respectively. C1P5 can be used for detection of HPV in cervical smears and biopsies and analysis of E6 expression in cell transformation studies. |
| Clone: |
C1P5 |
| Subclass: |
IgG1 |
| Applications: |
Immunohistochemistry (Paraffin Embedded), Immunoprecipitation, Western blot |
| Immunogen: |
Gel-purified HPV-18 E6-β-galactosidase fusion protein. |
| Reactivity: |
HPV infected human cells |
| Species raised in: |
Mouse: Balb/c |
| Fusion partner: |
NS-1 |
| Recommended growth conditions: |
DMEM 5% FCS |
| References: |
Banks L et al. 1987. J. Gen. Virol. 68:1351-1359.  |
| Notes: |
HPV-18: 15.8 kD; HPV-16: 17kDa |
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