| Antigen: |
CD45 |
| Relevance: |
CD45 is a transmembrane
tyrosine phosphatase that is present on all leukocytes.
CD45 regulates the threshold of T cell antigen receptor
(TCR) signaling through dephosphorylation of protein
tyrosine kinases (e.g. Lck and Fyn). CD45R and CD45RO
are two of multiple CD45 isoforms generated by alternative
splicing. CD45R is found on B lymphocyte and T lymphocyte
subsets. CD45RO is present on 50% of T cells, most granulocytes
and monocytes and most mature T cell tumours. Hle-1
can be used in a panel of several monoclonal antibodies
to characterise tumours. |
| Clone: |
Hle-1 (2D1) |
| Subclass: |
IgG1 |
| Applications: |
Immunohistochemistry (frozen sections), FACS, Immunofluorescence |
| Immunogen: |
Ficoll-Triosil-separated
human peripheral blood mononuclear cells |
| Reactivity: |
Human |
| Species raised in: |
Mouse: Balb/c |
| Fusion partner: |
NS1 |
| Recommended growth conditions: |
DMEM + 5% FCS |
| References: |
Bradstock KF et al. 1980.
J. Nat. Cancer Inst. 65:33-42 
Tchilian EZ et al. 2001. J. Immunol. 166(2):1308-13 |
| Notes: |
180-220 KkDa MW |
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