| Antigen: |
CD3 |
| Relevance: |
The CD3 complex, composed of five CD3 polypeptide chains, associates with the T cell antigen receptor (TCR) and is found on all mature human T lymphocytes. UCH-T1 can be used for the detection of T cell populations in peripheral blood and lymph nodes and the categorisation of T versus B cell lymphomas and leukaemias. Indication of prognosis in leukaemia and lymphoma. UCH-T1 has mitogenic activity. |
| Clone: |
UCH-T1 |
| Subclass: |
IgG1 |
| Applications: |
Radioimmunoassay, Immunohistochemistry (frozen sections), Immunofluorescence |
| Immunogen: |
Human infant thymocytes and Sezary cells. |
| Reactivity: |
Human |
| Species raised in: |
Mouse: Balb/c. |
| Fusion partner: |
P3/NS1/1-Ag4-1 |
| Recommended growth conditions: |
RPMI 1640 + 5% FCS. |
| References: |
Beverley P & Callard R. 1981. Euro. J. Immunol. 11(4):329-334 
Garson JA et al. 1982. Nature. 298:375-377
Dornan S et al. 2002. J. Biol. Chem. 277(3):1912-8 |
| Notes: |
Use: Enrichment of T cell populations by cell sorting or panning. There is mitogenic activity with this MAb |
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