| Antigen: |
AP-2 α and β forms. |
| Relevance: |
AP-2 is a family of developmentally
regulated transcription factors, which also play a role
in breast cancer and melanoma. AP-2β
may be important in cardiac and kidney development.
The AP-2 transcription factors form the OB2 complex
that has been shown to up-regulate c-erb-B2 transcription. |
| Clone: |
A6/2/2 |
| Subclass: |
IgG1
|
| Applications: |
Immunohistochemistry (Paraffin embedded), Western blot, Radioimmunoassay, ELISA, FACS |
| Immunogen: |
Peptide to C-Terminal of AP-2 Alpha (sequence: PNSHTDNNAKSSDKEEKHRK) |
| Reactivity: |
Human |
| Species raised in: |
- |
| Fusion partner: |
NSO |
| Recommended growth conditions: |
DMEM + 5% FCS |
| References: |
Gee JMW et al. 1999. J.
Pathol. 189:514-520 
Batsche E et al. 1998. Mol. Cell. Biol. 18(7):3647-3658 |
| Notes: |
Positive control:
Raji cells or breast carcinomas.
As the antibody also recognises AP-2beta, the epitope it recognises is probably the last 8 amino acids as these are common between alpha and beta. Immunohistology fixative formal saline with calcium paraffin embedded (10min microwave treatment required). |
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Please note that CRT supplies to distributors only. However, we are happy to direct researchers to the appropriate commercial party to obtain antibodies within our portfolio. Click here to view disclaimer information. |
