| Antigen: |
Lymphocyte Specific Protein-1 (LSP-1) |
| Relevance: |
Human lymphocyte-specific protein 1 is an F-actin binding phosphoprotein, which has an acidic N-terminal half and a basic C-terminal half. In the basic C-terminal half, there are amino acid sequences highly homologous to the actin-binding domains of two known F-actin binding proteins: caldesmon and the villin headpieces (CI, CII, VI, VII) |
| Clone: |
TPD153 |
| Subclass: |
IgG1, kappa |
| Applications: |
Western blot, Immunohistochemistry (frozen and paraffin sections), Immunoprecipitation |
| Immunogen: |
Tonsil cells |
| Reactivity: |
Human |
| Species raised in: |
Mouse |
| Fusion partner: |
NS-1 |
| Recommended growth conditions: |
RPMI 1640 + 10% FCS + penicillin (100U/ml) + streptomycin (100mg/l) + glutamine (2mM) + HAT |
| References: |
Pulford K, Jones M, Banham AH, Haralambieva E, Mason DY (1999) Lymphocyte-specific protein 1: a specific marker of human leucocytes. Immunol 96:262-271 
Marafioti T, Jabri L, Pulford K, Brousset P, Mason DY, Delsol G (2003) Leucocyte-specific protein (LSP1) in malignant lymphoma and Hodgkin's disease. Br J Haematol 120:671-678
Marafioti T, Mancini C, Ascani S, Sabattini E, Zinzani PL, Pozzobon M, Pulford K, Falini B, Jaffe ES, Muller-Hermelink HK, Mason DY, Pileri SA (2004) Leukocyte-specific phosphoprotein-1 and PU.1: two useful markers for distinguishing T-cell-rich B-cell lymphoma from lymphocyte-predominant Hodgkin's disease. Haematologica 89:957-964 |
| Notes: |
Please note this cell line has not been weaned out of HAT. Ultroser G can be used at 1% if the cells are not growing well |
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