CD21L clone R4/23

Anti-CD21L Antibody Profile

Antigen:	CD21L (Dendritic Reticulum Cells)
Relevance:	Dendritic reticulum cells form a meshwork in lymphoid follicles. R4/23 recognises a long form of CD21. R4/23 can be used to identify dendritic reticulum cells (or their remnants) in lymphoid tissues
Clone:	R4/23
Subclass:	IgM
Applications:	Western blot, Immunohistochemistry (frozen sections)
Immunogen:	Preparation of a lysate from a patient’s cells (CLL)
Reactivity:	Human
Species raised in:	Mouse
Fusion partner:	NS-1
Recommended growth conditions:	RPMI 1640 + 10% FCS + penicillin (100U/ml) + streptomycin (100mg/l) + glutamine (2mM) + HAT
References:	Stein H, Gerdes J, Schwab U, Lemke H, Mason DY, Ziegler A, Schienle W, Diehl V (1982) Identification of Hodgkin and Sternberg-Reed cells as a unique cell type derived from a newly-detected small-cell population. Int J Cancer 30:445-459. Naiem M, Gerdes J, Abdulaziz Z, Stein H, Mason DY (1983) Production of a monoclonal antibody reactive with human dendritic reticulum cells and its use in the immunohistological analysis of lymphoid tissue. J Clin Pathol 36:167-175. Heinen E, Lilet-Leclercq C, Mason DY, Stein H, Boniver J, Radoux D, Kinet-Denoel C, Simar LJ (1984) Isolation of follicular dendritic cells from human tonsils and adenoids. II. Immunocytochemical characterization. Eur J Immunol 14:267-273
Notes:	Please note this cell line has not been weaned out of HAT. Ultroser G can be used at 1% if the cells are not growing well

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