| Antigen: |
Integrin aX (CD11c; gp150/95 a subunit) |
| Relevance: |
Integrin aX is found on hairy cell leukaemias and malignant histiocytes and on tissue macrophages, monocytes, activated neutrophils and some T-cell clones. Integrin aX has utility for diagnsis of hariy cell leukaemia |
| Clone: |
KB90 |
| Subclass: |
IgG1, kappa |
| Applications: |
Western blot, Immunohistochemistry (frozen sections), FACS |
| Immunogen: |
Hairy cell leukaemia cells |
| Reactivity: |
Human |
| Species raised in: |
Mouse |
| Fusion partner: |
NS-1 |
| Recommended growth conditions: |
RPMI 1640 + 10% FCS + penicillin (100U/ml) + streptomycin (100mg/l) + glutamine (2mM) + HAT |
| References: |
MacDonald SM, Pulford K, Falini B, Micklem K, Mason DY (1986) A monoclonal antibody recognising the p150/95 leucocyte differentiation antigen. Immunology 59:427-431 
CD Guide for CD11c (1995) In Schlossman SF, et al (eds) Leucocyte Typing V, Vol 2 Oxford University Press, Oxford, New York and Tokyo, p 2004 |
| Notes: |
Please note this cell line has not been weaned out of HAT. Ultroser G can be used at 1% if the cells are not growing well |
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