| Antigen: |
Integrin αE (CD103) |
| Relevance: |
This antigen defines a developmentally important subset of T cells, namely mucosal T cells including all IEL (intraepithelial lymphocytes) and ~20% of lamina propria T cells. Integrin
αE is a member of the integrin subset that contains the beta7 subunit. Integrin
αE is a heterodimer comprising a 150kDa α chain and a 120kDa β chain. CD103 is selective marker for intestinal intra-epithelial T-cells. BP6 can be used in the diagnosis of enteropathy-associated lymphoma and hairy cell leukaemia |
| Clone: |
BP6 |
| Subclass: |
IgG1, kappa |
| Applications: |
Immunohistochemistry (frozen sections), Immunoprecipitation |
| Immunogen: |
Hairy cell spleen lysate |
| Reactivity: |
Human |
| Species raised in: |
Mouse |
| Fusion partner: |
NS-1 |
| Recommended growth conditions: |
RPMI 1640 + 10% FCS + penicillin (100U/ml) + streptomycin (100mg/l) + glutamine (2mM) + HAT |
| References: |
Micklem KJ, Dong Y, Willis A, Pulford KA, Visser L, Dürkop H, Poppema S, Stein H, Mason DY (1991) HML-1 antigen on mucosa-associated T cells, activated cells, and hairy leukemic cells is a new integrin containing the beta7 subunit. Am J Pathol 139:1297-1301.  |
| Notes: |
Please note this cell line has not been weaned out of HAT. Ultroser G can be used at 1% if the cells are not growing well |
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