| Antigen: |
Gastrokine2 (aka blottin) GKN2 Human Homologue |
| Relevance: |
The murine protein Gastrokine 2 (GKN-2, previously known as blottin) binds to mouse Trefoil Factor Family (TFF) and is found in the gastric surface of foveolar epithelial cells. The protein has a human homologue (GDDR/TF1Z1) and has similarities with GKN-1 another gastric foveolar protein. GKN-2 is also seen in the reparative surface epithelium of the colon in the UACL of Crohn's disease. GKN-2 may inhibit cell proliferation in contrast to GKN-1 which is a mitogen. GKN-2 may play a role in gastro-intestinal mucosal maintenance and repair through interactions TFF. Previous work has shown the GKN-2 is down regulated in gastric cancer. |
| Clone: |
GKN2 |
| Applications: |
Western, Immunofluorescence, Histocytochemistry, Histology, Paraffin embedded, Frozen |
| Immunogen: |
N-terminal residues 29-48 of the TFF2-AP binding protein |
| Reactivity: |
Mouse and Human |
| Species raised in: |
Rabbit |
| Notes: |
Serum tested both on westerns (mouse stomach epithelial extracts, upon which it also works at 1:1000-1:2000) and IHC on paraffin embedded normal human stomach (1:250)
Positive Controls:
Normal human (or mouse) stomach, with intact surface and/or pit epithelium. It is likely to be less expressed in gastric cancers. |
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