| Antigen: |
Mucin 1 (Muc1) |
| Relevance: |
MUC1 is a large cell surface
mucin glycoprotein expressed by most glandular and ductal
epithelial cells and some hematopoitic cell lineages.
In the vast majority of human carcinomas, this protein
is upregulated, poorly glycosylated and appears on the
cell surface in a non-polarised fashion. SM3 antibody
recognises this under-glycosylated form of MUC1 and
is therefore tunour specific |
| Clone: |
SM3 |
| Subclass: |
IgG1 |
| Applications: |
Immunohistochemistry (paraffin
embedded and frozen sections) |
| Immunogen: |
Hydrogen fluoride deglycosylated
milk mucin |
| Reactivity: |
Human |
| Species raised in: |
mouse- Balb/c |
| Fusion partner: |
NS2 |
| Recommended growth conditions: |
RPMI + 10% FCS |
| References: |
Burchell
et al. 1987. Cancer Research. 47: 5476-82. 
Burchell
et al. 1989. Int J Cancer. 44: 691-6 |
| Notes: |
Reacts very little with
normal tissue. Found to react with breast, colon
and ovarian carcinomas and adinocarcinoma. Positive
control: Ovarian, breast or colon carcinoma, normal
intestine or colon |
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