| Antigen: |
Tumour Necrosis Factor alpha (TNF alpha) |
| Relevance: |
Tumour necrosis factor alpha is a multifunctional cytokine with important pro-inflammatory actions |
| Clone: |
3-101-4 (aka 357-101-4) |
| Subclass: |
IgG1 |
| Applications: |
Immunoassays (ELISA, RIA), Immunoprecipitation, Strong neutralizing activity |
| Immunogen: |
Recombinant tumour necrosis factor alpha from E. coli |
| Reactivity: |
Human |
| Species raised in: |
Balb/C mice |
| Fusion partner: |
NS0 |
| Recommended growth conditions: |
RPMI1640 + 10% FCS |
| References: |
Production of hybridomas in the same fusion batch is described in Meager, A. et al. 1987. Hybridoma, 6: 305-311. 357-101-4 was later found to be more stable than the clones cited in this publication and have comparable performance.  |
| Notes: |
Binds to unknown conformational epitope distinct from the tip region; can therefore be paired with 2-179-E11, which recognizes epitope in tip region, in immunoassays |
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