| Antigen: |
Interleukin-1 alpha (IL-1 alpha) |
| Relevance: |
Interleukin 1 (IL-1), originally known as lymphocyte activating factor (LAF), is an important cytokine with diverse physiological effects. These range from T-cell activation and induction of fever and sleep to effects on astrocytes and fibroblast proliferation. IL-1 is primarily released from stimulated macrophages and monocytes, but also is released from several other cell types and is thought to play a key role in inflammatory and immune responses. IL-1 exists in two distinct forms (IL-1 alpha and beta) which show little sequence homology (around 25%). They bind the same cell surface receptor and elicit nearly identical biological responses |
| Clone: |
3B3 (aka 364/3B3-14) |
| Subclass: |
IgG 1 |
| Applications: |
Immunoprecipitation,
Immunoassay |
| Immunogen: |
Recombinant human Interleukin 1 |
| Reactivity: |
Human |
| Species raised in: |
Balb/C mice |
| Fusion partner: |
NSO |
| Recommended growth conditions: |
RPMI 1640 + 5% FCS |
| References: |
Thorpe, R et al. 1988 Lymphokine Research. 7 (2): 119-27  |
| Notes: |
Does not recognise IL-1beta, TNF alpha or ovalbumin. Positive control: recombinant Il-1 protein. Recognisies both recombinant and native IL-1. Can be used as a capture antibody in immunoassays when paired with one of our other IL-1 clones: 364/8C4-8 or 364/5C6-2 |
For further information about antibodies from CRT or to discuss sales or licensing options, please contact us at reagents@cancertechnology.com
Click here to view Notes and Disclaimer information |
