Anti-CD11C clone BU15

Anti-CD11C Antibody Profile

Antigen:	CD11C
Relevance:	Integrin aX is found on hairy cell leukaemias and malignant histiocytes and on tissue macrophages, monocytes, activated neutrophils and some T-cell clones. Integrin aX has utility for diagnosis of hairy cell leukaemia.
Clone:	BU15
Subclass:	IgG1
Applications:	FACS (1/10 1/50; use of 10 µl of the suggested working dilution to label 106 cells), Immunoprecipitation, Immunohistochemistry (frozen sections). Not suitable for paraffin embedded sections.
Immunogen:	Dendritic cells of synovial fluid
Reactivity:	Human, cynomolgus monkey and dog. Not yet tested in other species.
Species raised in:	Mouse
Fusion partner:	Plasmacytoma NS1/BALB/c mouse spleen cell; date of fusion: February 1984
Recommended growth conditions:	RPMI 1640 + 10% FCS
References:	Baker, M.P. et al. 1998 Blood 92(8):2830-43 Hogg, N. et al. 1986 Eur.J.Immunol. 16:240-8 Larson, R.s. & Springer, T.A. 1990 Immunol. Rev. 114:181-217 Myou, S. et al. 2002 Immunology 107:77-85 Rezzonico, R. et al. 2001 Blood 97:2932-40 Stewart, C.C. and Stewart, S.J. 1994 Methods Cell Biol. 41:39-60 Trowald-Wigh, G. et al. 1993 Vet. Immunol. Immunopathol. 38:297-310 Van der Vieren, M. et al. 1995 Immunity 1995 3(6):683-90 Yoshino, N. et al. 2000 Exp. Anim. 49(2):97-110 Leukocyte Typing III (1987), McMichael (ed.) Oxford University Press, Oxford, UK
Notes:

[back]